Research Article
Anti-inflammatory Effects of Erynagium Caucasicum Trautv extract in Carrageenan Model of Inflammation in Rat
Emran Habibi, Reza Azami, Hamed Fathi,
Saeed Yaghubi-Beklar, Farkhondeh
Razzaghi, Rami Ataee
Correspondence Address :
Rami Ataee
Thalassemia
Research Center
hemoglubinopathy institute,
Mazandaran University of Medical Sciences
Sari, Iran
Tel: +98 911 323 2804
Email: raminataee1349@gmail.com
Received on: , Accepted on: , Published on:
Citation: Emran Habibi, Reza Azami, Hamed Fathi, et al. (2018). Anti-inflammatory Effects of Erynagium Caucasicum Trautv extract in Carrageenan Model of Inflammation in Rat
Copyright: 2018 Rami Ataee, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: Eryngium caucasicum, in the family of 1umbelliferae (Apiaceae) 117 cultivated species excluding ornamentals have been recorded. Many pharmacological activities have been reported in Umbelliferae family. The aim of present study was to investigate anti-inflammatory activity of Eryngiun caucasicumTrautv inflorescence.
Materials and Methods: 30 rats were put in 3 treatment groups and 2 observed groups, were injected 200,400,800, mg/kg dosage of erungium and as positive control group injected with celecoxib, 100 mg/kg and for negative control groups normal saline 0.9% was injected peritoneally. 1 hour after extract injection, carrageenan as an inflammation producing agent, was injected on subcutaneous of feet. The rate of inflammation producing 3 hours later were studied by measuring the change produced in the volume of foot using a plethismometer apparatus and analyzed with ANOVA (p<0.001),
Results: The data showed that Eryngium caucasicum was good anti-inflammatory activity in 200 and 400 mg/kg dosages and that was dose- independent after 400 mg/kg.
Conclusion: According to this study we can introduce Eryngium caucasicum as potential anti-inflammatory medicinal herb which can be used in co- treatments of inflammatory episodes.
Keywords: Eryngium caucasicum, Inflammatory, Rat, Carrageenan